冰片对大鼠体内利福平药物动力学的影响Studies on the effects of borneol on the pharmacokinetics of rifampicin
程刚,吴寿荣,冯岩
CHENG Gang; WU Shou rong; FENG Yan (School of Pharmacy;
摘要(Abstract)：
研究冰片对利福平的药代动力学的影响。大鼠分为单用组和合用冰片组 ,采用高效液相色谱法研究大鼠灌胃给药后药物在大鼠体内的经时过程并计算药代动力学参数。合用组和单用组的T1/2ka分别为 1 8 36min和 2 2 70min,T1/2ke分别为 5 6 9 79min和 4 35 5 2min,Tmax分别为 94 0 3min和1 0 2 0 6min ,Cmax 分别为 1 2 6 2 μg/mL 和 8 70 μg/mL,AUC分别为 1 1 6 30 6 4 ( μg·min) /mL 和6 4 32 80 ( μg·min) /mL。冰片可显著提高利福平大鼠体内的生物利用度 ,明显改善药物的吸收
In this paper the effects of borneol on the pharmacokinetics of rifampicin were studied. By a cross over design, six rats were given ig rifampicin(RIF) 20 mg/kg with or without previous borneol 20 mg/kg after an overnight fast. The rifampicin in rats plasma was detected by the RP HPLC method and the pharmacokinetic parameters were calculated by 3P87 software. The results demonstrated that t 1/2ka were 18 36 min and 22 70 min , respectively, t 1/2ke were 569 79 min and 435 52 min , respectively. The peak plasma levels were 12 62 μg mL -1 at 94 03 min and 8 70 μg/mL at 102 06 min , respectively. The area under the plasma concentration time curves was 11 630 64 μg min mL -1 and 6 432 80μg·min·mL -1 , respectively. The results showed that the borneol could significantly enhances the absorption of the rifampicin.
关键词(KeyWords)：
冰片;利福平;药代动力学;联合药物治疗
borneol; rifampicin; pharmacokinetics; combination drug therapy
基金项目(Foundation): 辽宁省自然科学技术基金资助项目 ( 991 0 5 0 0 5 0 4 )
作者(Authors):
程刚,吴寿荣,冯岩
CHENG Gang; WU Shou rong; FENG Yan (School of Pharmacy;
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