刁玉林,刘祎,孟大利
DIAO Yu-lin,LIU Yi,MENG Da-li(School of Traditional Chinese Materia Medica

• 1:沈阳药科大学中药学院

摘要(Abstract)：

目的综述降血脂天然产物的研究进展,为在天然药物中寻找研究降血脂的药物提供参考。方法通过查阅国内外相关文献共11篇,对不同化学类别的天然产物的不同所属科进行分类。对兰科、山茶科、菊科、龙胆科、五加科、马尾藻科、茄科和桑科的降血脂药物,具体针对新化合物及结构新颖的天然产物进行综述。结果现已研究的、来源于天然产物的降血脂药物分布于多种植物中,具有不同的化学类别与结构特征。常见的有苷类、黄酮类和其他一些化合物等。结论综述结果可为天然降血脂药物的研究提供参考。
Objective To summarize the general situation of the natural hypolipidemic ingredients found recently.Methods International references was comprehensively reviewed;a detailed introduction about the natural hypolipidemic ingredients,mechanism of action and experiments were expatiated.Results The natural hypolipidemic agents with different chemical categories and structural characteristics that had been researched,the result demonstrated that they were distributed in many plants,marine life and some other species.Most of them are belong to glucosides,flavonoids and some other different chemical substances,which can be the sources for the research of hypolipidemic drugs.Conclusions This article will provide references for the study of the natural hypolipidemic ingredients.

关键词(KeyWords)： 降血脂;高甘油三酸酯;高血胆固醇;新天然产物
hypolipemia;hypertriglyceridemia;hypercholesterolemia;new natural products

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刁玉林,刘祎,孟大利
DIAO Yu-lin,LIU Yi,MENG Da-li(School of Traditional Chinese Materia Medica

参考文献(References)：

• [1]潘秀琴,李巍,朱震宏,等.高血脂相关因素分析[J].新疆医科大学学报,1999,4(19):66-68.
• [2]DU Xiao-ming,IRINO N,FURUSHO N,et al.Pharma-cologically active compounds in the Anoectochilus andGoodyera species[J].Journal of Natural Medicines,2008,62(2):132-148.
• [3]YOSHIKAWA M,MORIKAWA T,YAMAMOTO K,etal.Floratheasaponins A-C,acylated oleanane-type trit-erpene oligoglycosides with anti-hyperlipidemic activi-ties from flowers of the tea plant(Camellia sinensis)[J].Journal of Natural Products,2005,68(9):1360-1365.
• [4]MORIKAWA T,LI Xue-zheng,NISHIDA E,et al.Pe-rennisosides I-VII,acylated triterpene saponins withantihyperlipidemic activities from the flowers ofBellisperennis[J].Journal of Natural Products,2008,71(5):828-835.
• [5]SEZIK E,ASLAN M,YESILADA E,et al.Hypoglycae-mic activity ofGentiana olivieriand isolation of theac-tive constituent through bioassay-directed fractionationtechniques[J].Life Sciences,2005,76(11):1223-1238.
• [6]SHABANA M M,ELSHEREI M M,MOUSSA M Y,etal.Flavonoid constituents ofCarduncellus mareoticus(Del.)hanelt and their biological activities[J].Natu-ral Product Communications,2008,3(5):779-784.
• [7]SHABANA M M,ELSHEREI M M,MOUSSA M Y,etal.Investigation of phenolic constituents ofCarduncel-lus eriocephalus Boiss.var.albiflora Gauba and their bi-ological activities[J].Natural Product Communica-tions,2007,2(8):823-828.
• [8]EIBATRAN S A,ABDEL-AZIM N S,AB-DELSHAFEEK K A,et al.Flavonoids ofGomphocarpussinaicusand evaluation of some pharmacological activi-ties[J].Natural Product Sciences,2005,11(4):233-239.
• [9]KIM S N,CHOI H Y,LEE W J,et al.Sargaquinoicacid and sargahydroquinoic acid from Sargassumyezoense stimulate adipocyte differentiation throughPPARα/γactivation in 3T3-L1 cells[J].FEBS Let-ters,2008,582:3465-3472.
• [10]RAKESHM,AKANKSHA,JAYENDRA,et al.Coagul-anolide,a withanolide fromWithania coagulansfruitsand antihyperglycemic activity[J].Bioorganic&Me-dicinal Chemistry Letters,2008,18(24):6534-6537.
• [11]ELBESHBISHY H A,SINGAB A N B,SINKKONENJ,et al.Hypolipidemic and antioxidant effects ofMorusalbaL.(Egyptian mulberry)root bark fractions supple-mentation in cholesterol-fed rats[J].Life Sciences,2006,78(23):2724-2733.