张朔,姜典卓,邹宇清,武凤兰
Zhang Shuo 1; Jiang Dian-zhuo 1; Zou Yu-qing 2; Wu Feng-lan 1 (1. Pharmaceutical School of Peking University;

• 1:北京大学药学院
• 2:北京大学药学院
• 3:大连美罗股份新药特药公司
• 4:北京大学药学院 北京100083

摘要(Abstract)：

目的以甲壳胺和HPMC为骨架材料研究制备了VB1 HBS。方法对自制VB1 HBS体外释放度及其影响因素、体内外漂浮性能进行了考察。结果体外可持续漂浮 8h以上 ,体内观察 6h呈漂浮状态。其体外释放规律 1～ 1 2h内符合一级动力学模型。结论上法制得的处方 ,具有缓释和漂浮双重特性 ,初步达到了设计要求
Objective To study the preparation of VB 1-HBS from chritosan and HPMC.Methods VB 1-HBS was prepared by the direct compression. The dissolution and the floating ability of VB 1-HBS were also investigated.Results The results showed that in vitro VB 1-HBS floated continuously over 8 h in 0.1 mol/L HCl, and in vivo over 6 h. The in vitro release characteristics of VB1-HBS were shown primarily to be of the first order of kinetics in 1～ 12 h.Conclusions VB 1-HBS refered above exhibited typical sustained-release characteristics and good floating ability.

关键词(KeyWords)： 盐酸硫胺(VB1);流体动力学平衡控释系统(HBS);胃内滞留漂浮型缓释片;99mTc
thiamine (VB 1); HBS; floating sustained-release tablet; 99 mTc

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 张朔,姜典卓,邹宇清,武凤兰
Zhang Shuo 1; Jiang Dian-zhuo 1; Zou Yu-qing 2; Wu Feng-lan 1 (1. Pharmaceutical School of Peking University;

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