黄连解毒汤的抗血栓作用研究Research on antithrombotic effects of Huanglian Jiedu Decoction
付晓春,王敏伟
FU Xiao chun; WANG Min wei (School of Pharmacy;
摘要(Abstract)：
黄连解毒汤提取物 4 5 0、90 0、1 80 0mg/kg ,连续灌胃 3d,末次给药 1h后能显著延长小鼠体外凝血时间。家兔灌胃黄连解毒汤 1 5 0、30 0、6 0 0mg/kg,连续给药 3d,末次给药 1h后能明显延长血浆凝血酶原时间、白陶土活化部分凝血活酶时间及凝血酶时间 ,并能显著抑制ADP引起的血小板聚集。实验结果表明 ,黄连解毒汤具有明显的抗血栓形成作用。
The antithrombotic effect of Huandglian Jiedu Decoction (HLJDD) was studied in this paper.The thrombin time(TT),prothrombin time(PT),KPTT in rabbits and clotting time in mice were prolonged significintly.The platelet aggregation induced by ADP in the rabbits was inhibited.All those results suggested that HLJDD could refrain the formation of artery thrombus,the euglobulin lysis time (ELT) was not shortened,the weight of blood clotting in mice was not lightened,and those results showed that HLJDD can not dissolve arteris thrombus in the rabbits.
关键词(KeyWords)：
黄连解毒汤(HLJDD);复方丹参片(FFDST);抗血栓;血小板聚集;凝血时间
Huanglian Jiedu Decoction; Fufang Danshen Tablets; antithrombotic; platelet aggregation; clotting time
基金项目(Foundation):
作者(Authors):
付晓春,王敏伟
FU Xiao chun; WANG Min wei (School of Pharmacy;
参考文献(References)：
- [1]周本宏,罗顺德,蔡鸿生.黄连解毒汤的药理及临床应用研究进展[J].中成药,1991,13(11):38.
- [2]陈奇.中成药名方药理与临床[M].北京:人民卫生出版社,1998.131-133.
- [3]原中琉璃子.八味地黄丸、柴胡加龙骨牡蛎汤、大柴胡汤、黄连解毒汤对动脉粥样硬化的影响[J].国外医学,中医中药分册,1987,9(5):49-51.
- [4]史一峰,陈维泽.黄连解毒汤治疗中风后遗症34例[J].中国疗养医学,1996,5(3):46-47.
- [5]沈佳,孙春梅,徐荣源,等.HPLC法比较不同工艺制备的黄连解毒汤及日本汉方黄连解毒汤中的生物碱含量[J].中草药,2000,31(4):262-264.
- [6]陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1993.481.
- [7]陈奇.中药药理研究方法学[M].北京:人民卫生出版社,1993.615-616.
- [8]BornGVR .Aggregationofbloodplateletsbyadeno sinediphosphateanditsReversal[J].Nature,1962,194:927.
- [9]徐淑云.药理实验方法学[M].北京:人民卫生出版社,1991.838.
- [10]刘威,周重楚,师海波.脑栓通对血液系统的影响[J].中成药,1993,15(3):26-28.