闫志强,刘晓红,何仲贵
YAN Zhi-qiang,LIU Xiao-hong,HE Zhong-gui (School of Pharmacy

• 1:沈阳药科大学药学院
• 2:沈阳药科大学药学院
• 3:沈阳药科大学药学院 辽宁沈阳110016
• 4:辽宁沈阳110016

摘要(Abstract)：

目的为智能材料在药剂学中的应用提供理论依据。方法通过查阅近年国内外文献,对物理、化学和生物化学刺激敏感型智能材料的分类、各类材料构建相应智能给药系统的设计原理及其在药剂学中的应用进行详细的阐述。结果应用智能材料可制备出各种智能给药系统,通过感应病变部位各种环境信息的变化,实现药物的定点、定时、定量释放。结论虽然智能材料的应用迄今为止多数仍停留在实验研究阶段,但可以预见智能材料在药剂学领域中的应用会显现出更大的优势。
Objective To review the applications of intelligent materials in pharmaceutics.Methods Based on relevant literatures,this paper reviewed the studies on different types of intelligent materials responsive to physical,chemical and biochemical stimuli.The studies on the design principles of intelligent drug delivery systems and their applications in pharmaceutics were also summarized in the papers.Results Various types of intelligent drug delivery systems could be constructed by using responding intelligent materials.They made it possible to develop site-specific,time-specific and dose-specific drug delivery systems by responding to various triggers.Conclusions Although intelligent materials are still in their research phase,their applications will show great potential in pharmaceutics in the future.

关键词(KeyWords)： 智能材料;刺激敏感;智能给药系统
intelligent materials;stimuli sensitive;intelligent drug delivery systems

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 闫志强,刘晓红,何仲贵
YAN Zhi-qiang,LIU Xiao-hong,HE Zhong-gui (School of Pharmacy

参考文献(References)：

• [1]LOWMAN A M,PEPPAS N A.Pulsatile drug deliv-ery based on a complexstion-decomplexation mecha-nism[C]//DINH S M,DENUZZIO J D,COMFORTA R.Intelligent materials for controlled release:ACSSymposium Series 728.Washington DC:AmericanChemical Society,1999:30-42.
• [2]PEPPAS N A.Devices based on intelligent biopolymersfor oral protein delivery[J].Int J Pharm,2004,277(1/2):11-17.
• [3]GERASIMOV O V.Intracellular delivery of liposomecontents using pH-and light-activated plasmenyl-typeliposomes[C]//DINH S M,DENUZZIO J D,COM-FORT A R.Intelligent materials for controlled release:ACS Symposium Series 728.Washington DC:Ameri-can Chemical Society,1999:164-178.
• [4]UEKAMA K,HIRAYAMA F,IRIE T.Modificationsof drug Release by cyclodextrin derivatives[C]//DUCHENE D.New trends in cyclodextrins andderivatives.Paris:Editions de Santé,1991:409-446.
• [5]KOPECEK J.Smart and genetically engineered bioma-terials and drug delivery systems[J].Eur J Pharm Sci,2003,20(1):1-16.
• [6]LIU Xue-ming,WANG Li-shang,WANG Lin,et al.The effect of salt and pH on the phase transition be-haviours of temperature-sensitive copolymers based onN-isopropylacrylamide[J].Biomaterials,2004,25(25):5659-5666.
• [7]QIU Y,PARK K.Environment-sensitive hydrogels fordrug delivery[J].Adv Drug Delivery Rev,2001,53(3):321-339.
• [8]YUK S H,CHO S H,LEE H B,et al.Temperature-sensitive polymer system constructed with sodium algi-nate and poly(N,N-dimethylaminoethyl methacrylate-co-acrylamide)[C]//DINH S M,DENUZZIO J D,COMFORT A R.Intelligent materials for controlledrelease:ACS Symposium Series 728.Washington DC:American Chemical Society,1999:14-29.
• [9]OKU N,NARUSE R,DOI K,et al.Potential usage ofthermosensitive liposomes for macromolecule delivery[J].Biochim Biophys Acta,1994,1191(2):389-391.
• [10]YATVIN M B,WEINSTEIN J N,DENNIS W H,etal.Design of liposomes for enhanced local release ofdrugs by hyperthermia Science[J].Science,1978,202(4373):1290-1293.
• [11]MAMADA A,TANAKA T,KUNGWATCHAKUND,et al.Photoinduced phase transition of gels[J].Macromolecules,1990,23:1517-1519.
• [12]张景,张志荣.紫杉醇磁性非离子表面活性剂泡囊的研制及其质量评价[J].中国医院药学杂志,2001,21(8):454-455.
• [13]KWOK C,MOURAD P,CRUM L,et al.Self-assem-bled molecular structures as ultrasonically-responsivebarrier membranes for pulsatile drug delivery[J].JBiomed Mater Res,2001,57(2):151-164.
• [14]HASSAN C M,PEPPAS N A.Novel ethylene glycol-containing,pH-sensitive hydrogels for drug delivery ap-plications:“molecular gates”for insulin delivery[C]//DINH S M,DENUZZIO J D,COMFORT A R.Intel-ligent materials for controlled release:ACS SymposiumSeries 728.Washington DC:American Chemical Soci-ety,1999:54-69.
• [15]ISHIHARA K,KOBAYASHI M,ISHIMARU N,etal.Glucose induced permeation control of insulinthrough a complex membrane consisting of immobilizedglucose oxidase and a poly(amine)[J].Polym J,1984,16(8):625-631.
• [16]MAKINO K,MACK E J,OKANO T,et al.A micro-capsule self-regulating delivery system for insulin[J].JControl Release,1990,12(3):235-239.
• [17]ZHANG R,TANG M,BOWYER A,et al.Synthesisand characterization of aD-glucose sensitive hydrogelbased on CM-dextran and concanavalin A[J].Reactiveand Functional Polymers,2006,66(7):757-767.
• [18]MIYATA T,JIKIHARA A,NAKAMAE K,et al.Preparation of poly(2-glucosyloxyethyl methacrylate)-concanavalin A complex hydrogel and its glucose-sensi-tivity[J].Macromol Chem Phys,1996,197(3):1135-1146.
• [19]KITANO S,KOYAMA Y,KATAOKA K,et al.Anovel drug delivery system utilizing a glucose respon-sive polymer complex between poly(vinyl alcohol)andpoly(-Nvinyl-2-pyrrolidone)with a phenylboronic acidmoiety[J].J Control Release,1992,19(1/2/3):162-170.
• [20]BASAN H,G M DERELIOLU M,TEVFIK O M.Release characteristics of salmon calcitonin from dex-tran hydrogels for colon-specific delivery[J].Eur JPharm Biopharm,2007,65(1):39-46.
• [21]赖俊英,李文静,王红军,等.结肠靶向偶氮高分子的合成及其体外降解性能[J].高分子学报,2007(1):8-14.
• [22]DAVIS S C,SZOKA F C.Conditionally stable lipo-some for gene delivery[C]//DINH S M,DENUZZIOJ D,COMFORT A R.Intelligent materials for con-trolled release:ACS Symposium Series 728.Washing-ton DC:American Chemical Society,1999:179-189.
• [23]MIYATA T,ASAMI N,URAGAMI T,et al.A re-versibly antigen responsive hydrogel[J].Nature,1999,399(6738):766-769.