萘哌地尔的合成Synthesis of Naftopidil
王绍杰,孙殿春,王松青,牟艳华
WANG Shao jie 1; SUN Dian chun; WANG Song qing; MU Yan hua (Department of Pharmaceutics;
摘要(Abstract)：
以α 萘酚为原料 ,通过与环氧氯丙烷反应得到 3 (1 萘氧基 ) 1,2 环氧丙烷 ,再与 1 (2 甲氧苯基 )哌嗪反应得以萘哌地尔 ,总收率为 49 3%。
Starting from α naphthol,via the reaction with epichlorohydrin,2,3 epoxy 1 (1 naphthyloxy) propane was obtained.This intermediate reacted with 1 (2 methoxyphenyl)piperazine to afford Naftopdil,the overall yield was 49 3%.
关键词(KeyWords)：
萘哌地尔;合成
Naftopidil; synthe@
基金项目(Foundation):
作者(Authors):
王绍杰,孙殿春,王松青,牟艳华
WANG Shao jie 1; SUN Dian chun; WANG Song qing; MU Yan hua (Department of Pharmaceutics;
参考文献(References)：
- [1]YamaguchiOsamu .Dose dependenteffectsandclinicalusefulnessofNaftopidil(KT 6 11)onurinaryobstructioncausedbybenign prostatichyperplasia double blindcomparativestudycomparedwithplacebo [J].ClinicalReport ,1997,2 1(3) :1315 136 0 .
- [2 ]WitteEC ,KurtStach ,ThielMax ,etal.1 [3 (Naphth 1 yloxy) 2 hydroxypropyl] piperazinecompoundsandtherapeuticcompositions [P].USPatent:39976 6 6 ,1976 12 14.
- [3]PollardCB ,PerjnandezJB .Derivativesofpiperazine .XXXII. 1 Aryl 4 (2 hydroxy 3 aryloxypropyl) piper azines [J].JOrgChem ,195 8,2 3 :1935 1937.