张文鹤,秦斌,游松
ZHANG Wenhe,QIN Bin,YOU Song

• 1:沈阳药科大学生命科学与生物制药学院

摘要(Abstract)：

目的探究尼克酰胺酶法再生系统及其主要耦联酶系在药物合成中的应用。方法查阅近10年涉及尼克酰胺酶法再生系统参与生物催化法合成药物的相关文献,研究尼克酰胺酶法再生系统的酶系及相关耦联酶系在药物合成中的应用,以及优化再生系统的有效方法。结果尼克酰胺辅酶再生系统是利用生物催化实现药物合成的重要环节,要综合考虑反应参与的酶系、反应体系的诸多因素,使辅酶高效再生。结论酶法再生系统将有利于昂贵的尼克酰胺辅酶有效再生,使生物催化反应顺利进行,为手性化合物的合成提供新思路和新方法。
Objective To investigate the application of nicotinamide enzymatic regeneration system and its main coupling enzyme system in pharmaceutical synthesis. Methods The literatures that refer to the biocatalysic reactions associated with nicotinamide enzymatic regeneration in pharmaceutical synthesis were investigated. The emzymes which can regenerate the nicotinamide coenzymes,their coupling enzyme systems,and some methods to optimize nicotinamide enzymatic regeneration system were researched. Results Nicotinamide enzymatic regeneration system is an important part of biocatalysis in pharmaceutical synthesis.It is necessary to consider the factors involved in the enzyme and reaction system and make the regeneration system efficiently. Conclusion The nicotinamide enzymatic regeneration system will be beneficial. It can make the biocatalytic reaction proceed smoothly,and provide newideas and means for the synthesis of chiral compounds.

关键词(KeyWords)： 尼克酰胺辅酶再生;生物催化;药物中间体;手性化合物
nicotinamide coenzyme regeneration;biocatalysis;pharmaceutical intermediate;chiral compound

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金资助项目(81602993)

作者(Author): 张文鹤,秦斌,游松
ZHANG Wenhe,QIN Bin,YOU Song

DOI: 10.14066/j.cnki.cn21-1349/r.2018.07.014

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