崔丹丹,蒋革,罗锋
CUI Dan-dan,JIANG Ge,LUO Feng

• 1:大连大学生命科学与技术学院

摘要(Abstract)：

目的综述经不同种表面修饰的金纳米颗粒用作载体传递方面的研究进展。方法参考国内外30余篇相关文献,将该领域的相关信息进行分析、归纳与总结。结果阐述了经有机配体和生物分子两类修饰后,金纳米颗粒在载体传递方面的应用。结论表面修饰的金纳米颗粒在载体传递方面具有极其广阔的应用前景。
Objective To summarize the delivery applications of gold nanoparticles with different kinds of surface-modification in recent years.Methods According to the recent relevant literature,the preparation of gold nanoparticles with different kinds of surface-modification were summarized and analyzed.Results The applications of gold nanoparticles with two broad categories functionalization,organic ligand and biomolecule coatings,in delivery were reviewed.Conclusions Gold nanoparticles with different kinds of surfacemodification in delivery is promising.

关键词(KeyWords)： 金纳米颗粒;有机配体;生物分子;表面修饰;载体传递
gold nanoparticles;organic ligands;biomolecule coatings;surface-modified;delivery

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 崔丹丹,蒋革,罗锋
CUI Dan-dan,JIANG Ge,LUO Feng

DOI: 10.14066/j.cnki.cn21-1349/r.2014.10.015

参考文献(References)：

• [1]黄琴琴,王永禄,李学明.纳米载体材料毒理学效应及其作用机制研究进展[J].中国药房,2011,22(21):2004-2007.
• [2]BRADLEY D,CHAEKYU K,VINCENT M.Gold nanoparticle platforms as drug and biomacromolecule delivery systems[J].J Control Release,2010,148(1):122-127.
• [3]袁帅,刘峥,马肃.纳米金粒子的理化性质、制备及修饰技术和应用研究现状及进展[J].材料导报,2012,26(5):52-57.
• [4]潘运龙,赵晓旭,覃莉,等.纳米金对表阿霉素的增敏作用[J].中华实验外科杂志,2011,28(4):533-535.
• [5]郭筱兵,李忠海,黎继烈,等.金纳米粒子在食品检测领域中的研究进展[J].食品工业科技,2013,34(5):368-371.
• [6]卢耀勇,王冬晓,王建国,等.纳米金-聚乙烯亚胺基因载体的制备[J].现代生物医学进展,2013,13(20):3807-3810.
• [7]王平波.形状可控金纳米粒子的制备及表征[D].兰州:兰州理工大学,2009.
• [8]JIANG Wen,KIM B Y,RUTKA J T,et al.Nanoparticle-mediated cellular response is size-dependent[J].Nat Nano,2008,3(3):145-150.
• [9]THOMAS M,KLIBANOV A M.Conjugation to gold nanoparticles enhances polyethylenimine's transfer of plasmid DNA into mammalian cells[J].Proc Natl Acad Sci,2003,100(16):9138-9143.
• [10]WANG Hao,CHEN Yong,LI Xiao-yun,et al.Synthesis of oligo(ethylenediamino)-beta-cyclodextrin modified gold nanoparticle as a DNA concentrator[J].Pharm,2007,4(2):189-198.
• [11]MIN Y L,SANG J P,SEI K H,et al.Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex[J].ACS Nano,2011,5(8):6138-6147.
• [12]VERMA A,UZUN O,HU Ying,et al.Surfacestructureregulated cell-membrane penetration by monolayer-protected nanoparticles[J].Nat Mater,2008,7(7):588-595.
• [13]GHOSH P,YANG Xiao-chao,ARVIZO R,et al.Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles[J].J Am Chem Soc,2010,132(8):2642-2645.
• [14]JOSHI H M,BHUMKAR D R,JOSHI K,et al.Gold nanopartncles as carriers for efficient transmucosal insulin delivery[J].Langmuir,2006,22(1):300-305.
• [15]KIM B Y,RUTKA J T,CHAN W C.Nanomedicine[J].N Engl J Med,2010,363(25):2434-2443.
• [16]CHOI C H J,ALABI C A,WEBSTER P,et al.Mechanism of active targeting in solid tumors with transferrincontaining gold nanoparticles[J].Proc Natl Acad Sci USA,2010,107(3):1235-1240.
• [17]赵晓旭,潘运龙,胡杨志,等.纳米金-表阿霉素复合体的体外抗肿瘤作用[J].中山大学学报,2012,33(2):172-177.
• [18]HWU J R,LIN Y S,SHIEH D B,et al.Targeted paclitaxel by conjugation to iron oxide and gold nanoparticles[J].J Am Chem Soc,2009,131(1):66-68.
• [19]AGASTI S S,CHOMPOOSOR A,KIM C K,et al.Photoregulated release of caged anticancer drugs from gold nanoparticles[J].J Am Chem Soc,2009,131(16):5728-5729.
• [20]NAKANISHI J,NAKAYAMA H,HORIKE Y.Lightregulated activation of cellular signaling by gold nanoparticles that capture and release amines[J].J Am Chem Soc,2009,131(11):3822-3823.
• [21]TORCHILIN V.Tumor delivery of macromolecular drugs based on the EPR effect[J].Adv Drug Deliv Rev,2011,63(3):131-135.
• [22]PACIOTTI G F,MYER L,GOIA D,et al.Colloidal gold:a noval nanoparticle vector for tumor directed drug delivery[J].Drug Delivery,2004,11(3):169-183.
• [23]KIM E Y,SCHULZ R,WOLINSKY S M,et al.Gold nanoparticle-mediated gene delivery induce widespread changes in the expression of innate immunity genes[J].Gene Ther,2012,19(3):347-353.
• [24]OISHI M,NAKAOGAMI J,ISHII T,et al.Smart PEGylated gold nanoparticles for the cytoplasmic delivery of siRNA to induced enhanced gene silencing[J].Chem Lett,2006,35(9):1046-1047.
• [25]JAYAGOPAL A,HALFPENNY K C,WRIGHT D W,et al.Hairpin DNA-functionalized gold colloids for the imaging of mRNA in live cells[J].J Am Chem Soc,2010,132(28):9789-9796.
• [26]SUN Lin-lin,LIU Dia-njun,WANG Zhen-xin.Functional gold nanoparticle-peptide complexes as cell-targeting agents[J].Langmuir,2008,24:10293-10297.
• [27]BASTUS N G,SANCHEZ T E,PUJALS S,et al.Homogeneous conjugation of peptides onto gold nanoparticles enhances macrophage response[J].ACS Nano,2009,3(6):1335-1344.
• [28]GONG T,OLIVO M,YOUNG K T,et al.Engineering bioconjugated gold nanospheres and gold nanorods as label-free plasmon scattering probes for ultrasensitive multiplex dark-field imaging of cancer cells[J].J Biomed Nanotecgnol,2013,9(6):985-991.
• [29]PARK C,YOUN H,KIM C,et al.Cyclodextrin-covered gold nanoparticles for targeted delivery of an anticancer drug[J].J Mater Chem,2009,19:2310-2315.
• [30]LI Dan,LI Pei-cai,WANG Er-kang,et al.The effect of nocodazole on the transfection efficiency of lipid-bilayer coated gold nanoparticles[J].Biomaterials,2009,30(7):1382-1388.
• [31]KOJIMA C,HIRANO Y,KONO K,et al.Preparation and characterization of complexes of liposomes with gold nanoparticles[J].Colloids Surf B,2008,66(2):246-252.
• [32]WU Cong-yu,YU Cong,CHU Mao-quan.A goldnanoshell with a silica inner shell synthesized using liposome templates for doxorubicin loading and near-infrared photothermal theray[J].Int Nanomedicine,2011,6:807-813.